4.1 Article

Acid cleavable PEG-lipids for applications in a ternary gene delivery vector

Journal

MOLECULAR BIOSYSTEMS
Volume 4, Issue 6, Pages 532-541

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b719782a

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Funding

  1. Biotechnology and Biological Sciences Research Council [BBS/B/03645] Funding Source: Medline

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A novel class of pH-sensitive PEG lipids bearing acid-cleavable acetal linkages and short PEG chains have been synthesised and used in ternary vector formulations. The cleavage pH was influenced by structural components including the terminal PEG moiety and spacer length.

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