Journal
MOLECULAR BIOLOGY REPORTS
Volume 45, Issue 6, Pages 2913-2923Publisher
SPRINGER
DOI: 10.1007/s11033-018-4358-6
Keywords
MiRNA; Pathway; Therapeutics; Clinical trials
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Funding
- National Natural Science Foundation of China [31502056]
- Youth Talent Development Plan of Shanghai Municipal Agricultural System [20170116]
- Young Scientist Plan of Shanghai Academy of Agricultural Sciences [ZP173]
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Multidrug resistance (MDR) is still a major reason for therapeutic failure in cancers. The mechanisms underlying MDR are multifactorial and are not fully understood. miRNAs are evolutionarily conserved non-coding RNAs that function as key post-transcriptional regulators of gene expression. Emerging evidence indicates a vital role of miRNAs in the resistance to cancer treatments and suggests their potential for cancer therapy, as they can modulate multiple mechanisms link to the development of MDR. This review summarizes the recent findings on the role of miRNAs in MDR, and highlights the molecular targets and mechanisms of miRNA regulated pathways in MDR. Finally, the challenges and prospects of miRNA-targeted therapies for reversing drug resistance are reviewed.
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