4.5 Article

Genetic diversity and population structure in wild Sichuan rhesus macaques

Journal

MOLECULAR BIOLOGY REPORTS
Volume 40, Issue 4, Pages 3033-3041

Publisher

SPRINGER
DOI: 10.1007/s11033-012-2377-2

Keywords

DNA typing; Short tandem repeat; Rhesus macaques population structure

Funding

  1. National Natural Science Foundation of China [30970383]
  2. National Institutes of Health [R24RR05090, R24RR025871]

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Because wild rhesus macaque (Macaca mulatta) populations have suffered major declines, there is a growing need to characterize their genetic and population structure in order to protect the genetic integrity of this species. In this study, we genotyped a sample comprising 120 wild rhesus macaques from six sites in Sichuan Province for 30 nuclear microsatellite (STR) loci using an ABI 3130xl genetic analyzer. Bayesian analyses and PCA clearly differentiated monkeys from Heishui from those at other sites. The samples from all six sites exhibited high gene diversity suggesting that the Sichuan wild rhesus macaque populations are not threatened by a lack of genetic diversity. Deviation from Hardy-Weinberg equilibrium was more frequent in the Danba and Heishui populations. This may be due to the more fragmented habitat and less disturbance by humans in this area that foster greater subpopulation structuring than occurs in eastern China. We suggest that this population subdivision is the result of both long-term geographic barriers and human activity.

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