Journal
MOLECULAR BIOLOGY REPORTS
Volume 40, Issue 2, Pages 1735-1741Publisher
SPRINGER
DOI: 10.1007/s11033-012-2224-5
Keywords
Pancreatic cancer; EphB4 receptor; Angiogenesis; CD34
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In the study, we investigated the correlation between EphB4 receptor expression and the angiogenesis of pancreatic cancer. EphB4 receptor is unevenly distributed or distributed with small patches in pancreatic ductal cell cancer. While EphB4 receptor was not expressed in normal pancreatic tissues. It can be observed that the mRNA of EphB4 receptor is high expressed in all 15 cases of pancreatic ductal cell cancer tissues but not expressed in normal pancreatic tissues. Finally, positive correlation was observed between the mRNA expression level of EphB4 receptor and MVD. Immunohistochemical analysis showed that EphB4 receptor protein expression was related to tumor differentiation and clinical stage. It can be observed that MVD is relevant to histological differentiation and clinical stage. EphB4 receptor is correlated to the initiation, progression and tumor angiogenesis. In conclusion, EphB4 receptor maybe a promising targeted goal of antiangiogenic formation, which provides a new approach and method for tumor treatment.
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