Journal
MOLECULAR BIOLOGY REPORTS
Volume 39, Issue 5, Pages 5323-5330Publisher
SPRINGER
DOI: 10.1007/s11033-011-1331-z
Keywords
FABP4; Marbling score; Meat quality; Hanwoo (Korean cattle); SNP
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Funding
- Rural Development Administration, Republic of Korea [PJ008135012011]
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This study was aimed to search new genetic variants in the bovine FABP4 gene as molecular markers for meat quality and carcass traits. PCR-RFLP analysis revealed that three SNPs located at nucleotide positions g.2834C > G, g.3533T > A, and g.3691G > A were identified based on a GenBank accession number (NC_007312.4). Sequence analysis revealed that SNPs were located in intron 1 (g.2834C > G) and 2 (g.3533T > A), and an exon 3 (g.3691G > A), showing allele frequencies as 0.592, 0.579, and 0.789, respectively. Genetic variabilities of heterozygosity (He) and polymorphic information contents (PIC) were estimated for g.2834C > G (0.608 and 0.531), g.3533T > A (0.615 and 0.539), and g.3691G > A (0.498 and 0.401) loci, respectively. A SNP located in the exon 3 of FABP4 was characterized and associated with desirable increases of MS (marbling scores) and MG (meat quality grades) in Hanwoo. The statistical analysis revealed that additive effects by GG genotypes in g.3691G > A SNP were significantly greater than AA genotypes in MS and MG traits. These findings suggest that the FABP4g.3691G > A SNP will be a useful candidate locus to maximize economic benefits for cattle populations.
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