Journal
MOLECULAR BIOLOGY REPORTS
Volume 38, Issue 7, Pages 4705-4708Publisher
SPRINGER
DOI: 10.1007/s11033-010-0605-1
Keywords
Cattle; Thyroglobulin gene; Polymorphism
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Funding
- earmarked fund for Modern Agro-industry Technology Research System [nycytx-38]
- New Variety of Transgenic Organism Great Breeding Program [2008ZX08007-002, 2009ZX 08009-157B]
- National Natural Science Foundation of China [30871774]
- Beijing Natural Science Foundation [6093024]
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Thyroid hormones play an important role in regulating metabolism and can affect homeostasis of fat deposition. The gene encoding thyroglobulin (TG), producing the precursor for thyroid hormones, has been proposed as a positional and functional candidate gene for a QTL with an effect on fat deposition. In the present study, we identified 6 novel SNPs at the 3' flanking region of the TG gene. The SNP marker association analysis indicated that the T354C, G392A, A430G and T433G SNP markers were significantly associated with marbling score (P < 0.05). Animals with the new homozygote genotype had higher marbling score than those with the other genotypes. Otherwise, the linkage disequilibrium analysis indicated that these four SNPs were completely linked (r (2) = 1). Results from this study suggest that TG gene-specific SNP may be a useful marker for meat quality traits in future marker assisted selection programs in beef cattle.
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