Journal
MOLECULAR BIOLOGY REPORTS
Volume 37, Issue 1, Pages 535-540Publisher
SPRINGER
DOI: 10.1007/s11033-009-9706-0
Keywords
MC4R gene; Polymorphism; Meat quality; Carcass traits; Qinchuan cattle
Categories
Funding
- National 863'' Program of China [2006AA10Z1A1]
- Natural Sustaining Program for Agriculture, Forestry, Animal and Plant breeding [2006BAD01A10-3]
- Scientific and Technological Innovation Program of Shaanxi Province [2007ZDCY-01]
- Talent Foundation for Northwest A F University
Ask authors/readers for more resources
MC4R belongs to a seven-transmembrane G-protein-coupled receptor which may regulate body composition and insulin action. Many mutations in the MC4R gene are associated with obesity, energy expenditure and serum triglyceride levels in human and animals. Six mutations in the MC4R gene were identified in our study (-293C > G, -193A > T, -192T > G, -129A > G, -84T > C and 1,069C > G). The -129A > G was significantly associated with live weight (LW) (P < 0.05), Cattle with the genotypes AG and GG had higher LW than genotype AA. The 1,069C > G was significantly associated with LW, carcass weight (CW), backfat thickness and marbling score (MS). Cattle with the genotype GG had higher LW, CW and MS than genotype CC; Cattle with the genotypes GG and CG had higher MS than CC. The results suggested that -129A > G and 1,069C > G SNP of the MC4R gene may be useful as a genetic marker for carcass and meat quality traits in Qinchuan cattle.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available