Journal
SCIENCE
Volume 348, Issue 6232, Pages 340-343Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1260384
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Funding
- U.S. National Institutes of Health [R01 CA103866, R01 CA129105, R37 AI047389]
- Foundations' Post Doc Pool
- Academy of Finland
- Juselius Foundation
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By dividing asymmetrically, stem cells can generate two daughter cells with distinct fates. However, evidence is limited in mammalian systems for the selective apportioning of subcellular contents between daughters. We followed the fates of old and young organelles during the division of human mammary stemlike cells and found that such cells apportion aged mitochondria asymmetrically between daughter cells. Daughter cells that received fewer old mitochondria maintained stem cell traits. Inhibition of mitochondrial fission disrupted both the age-dependent subcellular localization and segregation of mitochondria and caused loss of stem cell properties in the progeny cells. Hence, mechanisms exist for mammalian stemlike cells to asymmetrically sort aged and young mitochondria, and these are important for maintaining stemness properties.
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