Journal
SCIENCE
Volume 348, Issue 6230, Pages 80-86Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaa4972
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Funding
- NIH [R01CA154426]
- Burroughs Wellcome Career in Medical Sciences Award
- Searle Scholars Award
- Cancer Research Institute Investigator Award
- Hoffman-LaRoche
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A host's microbiota may increase, diminish, or have no effect at all on cancer susceptibility. Assigning causal roles in cancer to specific microbes and microbiotas, unraveling host-microbiota interactions with environmental factors in carcinogenesis, and exploiting such knowledge for cancer diagnosis and treatment are areas of intensive interest. This Review considers how microbes and the microbiota may amplify or mitigate carcinogenesis, responsiveness to cancer therapeutics, and cancer-associated complications.
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