Journal
SCIENCE
Volume 350, Issue 6264, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aac9462
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Funding
- McKnight Scholar Award
- Arnold and Mabel Beckman Foundation Young Investigator Award
- Deutsche Forschungsgemeinschaft (DFG) [EXC 307]
- German Federal Ministry of Education and Research (BMBF
- BCCN Tubingen) [FKZ 01GQ1002]
- [DP1EY023176]
- [DP1OD008301]
- [R21EB016223]
- [P30EY002520]
- [T32EY07001]
- [F30MH095440]
- [T32GM007330]
- [T32EB006350]
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Since the work of Ramon y Cajal in the late 19th and early 20th centuries, neuroscientists have speculated that a complete understanding of neuronal cell types and their connections is key to explaining complex brain functions. However, a complete census of the constituent cell types and their wiring diagram in mature neocortex remains elusive. By combining octuple whole-cell recordings with an optimized avidin-biotin-peroxidase staining technique, we carried out a morphological and electrophysiological census of neuronal types in layers 1, 2/3, and 5 of mature neocortex and mapped the connectivity between more than 11,000 pairs of identified neurons. We categorized 15 types of interneurons, and each exhibited a characteristic pattern of connectivity with other interneuron types and pyramidal cells. The essential connectivity structure of the neocortical microcircuit could be captured by only a few connectivity motifs.
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