Journal
MOLECULAR BIOLOGY OF THE CELL
Volume 24, Issue 18, Pages 2765-2768Publisher
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E13-03-0165
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Funding
- U.S. National Science Foundation [CHE-1058809]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1058809] Funding Source: National Science Foundation
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Lipid raft is the name given to the tiny, dynamic, and ordered domains of cholesterol and sphingolipids that are hypothesized to exist in the plasma membranes of eukaryotic cells. According to the lipid raft hypothesis, these cholesterol- and sphingolipid-enriched domains modulate the protein-protein interactions that are essential for cellular function. Indeed, many studies have shown that cellular levels of cholesterol and sphingolipids influence plasma membrane organization, cell signaling, and other important biological processes. Despite 15 years of research and the application of highly advanced imaging techniques, data that unambiguously demonstrate the existence of lipid rafts in mammalian cells are still lacking. This Perspective summarizes the results that challenge the lipid raft hypothesis and discusses alternative hypothetical models of plasma membrane organization and lipid-mediated cellular function.
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