Journal
MOLECULAR BIOLOGY OF THE CELL
Volume 24, Issue 23, Pages 3663-3674Publisher
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E13-06-0302
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Funding
- Cancer Research UK [C25017/A9006, A13082]
- Association for International Cancer Research
- Cancer Research UK [13082] Funding Source: researchfish
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Recently it was shown that both recycling endosome and endosomal sorting complex required for transport (ESCRT) components are required for cytokinesis, in which they are believed to act in a sequential manner to bring about secondary ingression and abscission, respectively. However, it is not clear how either of these complexes is targeted to the midbody and whether their delivery is coordinated. The trafficking of membrane vesicles between different intracellular organelles involves the formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes. Although membrane traffic is known to play an important role in cytokinesis, the contribution and identity of intracellular SNAREs to cytokinesis remain unclear. Here we demonstrate that syntaxin 16 is a key regulator of cytokinesis, as it is required for recruitment of both recycling endosome-associated Exocyst and ESCRT machinery during late telophase, and therefore that these two distinct facets of cytokinesis are inextricably linked.
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