Journal
MOLECULAR BIOLOGY OF THE CELL
Volume 23, Issue 13, Pages 2407-2411Publisher
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E12-01-0073
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There has been a dramatic shift of attention from the ciliary axoneme to the ciliary membrane, much of this driven by the appreciation that cilia play a widespread role in sensory reception and cellular signaling. This Perspective focuses attention on some of the poorly understood aspects of ciliary membranes, including the establishment of ciliary and periciliary membrane domains, the trafficking of membrane components into and out of these membrane domains, the nonuniform distribution of ciliary membrane components, the regulation of membrane morphogenesis, functional collaboration between the axoneme and the membrane, and the evolving field of therapeutics targeted at the ciliary membrane.
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