Journal
SCIENCE
Volume 349, Issue 6244, Pages 184-187Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaa4056
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Funding
- National Eye Institute [EY017366]
- National Institute of Mental Health [MH099611]
- Sloan Foundation
- McKnight Foundation
- National Science Foundation CAREER award [IIS-1150186]
- National Institutes of Health under Ruth L. Kirschstein National Research Service from the National Institute on Drug Abuse [T32DA018926]
- National Institutes of Health under Ruth L. Kirschstein National Research Service from National Eye Institute [T32EY021462]
- Direct For Computer & Info Scie & Enginr
- Div Of Information & Intelligent Systems [1150186] Funding Source: National Science Foundation
- Div Of Information & Intelligent Systems
- Direct For Computer & Info Scie & Enginr [1601115] Funding Source: National Science Foundation
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Neurons in the macaque lateral intraparietal (LIP) area exhibit firing rates that appear to ramp upward or downward during decision-making. These ramps are commonly assumed to reflect the gradual accumulation of evidence toward a decision threshold. However, the ramping in trial-averaged responses could instead arise from instantaneous jumps at different times on different trials. We examined single-trial responses in LIP using statistical methods for fitting and comparing latent dynamical spike-train models. We compared models with latent spike rates governed by either continuous diffusion-to-bound dynamics or discrete stepping dynamics. Roughly three-quarters of the choice-selective neurons we recorded were better described by the stepping model. Moreover, the inferred steps carried more information about the animal's choice than spike counts.
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