Journal
SCIENCE
Volume 347, Issue 6227, Pages 1265-1269Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1256682
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Funding
- NIH [DK091618, EY016807, NS066457, RR032100, P30 CA014195, P30 EY019005]
- American Federation for Aging Research [M14322]
- American Heart Association [13BGIA17260057]
- H.A. and Mary K. Chapman Trust
- Aginsky Research Scholar Award
- Leona M. and Harry B. Helmsley Charitable Trust [2012-PG-MED002]
- Glenn Center for Aging
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Circadian clocks orchestrate periods of rest or activity and feeding or fasting over the course of a 24-hour day and maintain homeostasis. To assess whether a consolidated 24-hour cycle of feeding and fasting can sustain health, we explored the effect of time-restricted feeding (TRF; food access limited to daytime 12 hours every day) on neural, peripheral, and cardiovascular physiology in Drosophila melanogaster. We detected improved sleep, prevention of body weight gain, and deceleration of cardiac aging under TRF, even when caloric intake and activity were unchanged. We used temporal gene expression profiling and validation through classical genetics to identify the TCP-1 ring complex (TRiC) chaperonin, the mitochondrial electron transport chain complexes, and the circadian clock as pathways mediating the benefits of TRF.
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