Journal
SCIENCE
Volume 348, Issue 6230, Pages 74-80Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaa6204
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Funding
- National Cancer Institute
- American Cancer Society
- Breast Cancer Research Foundation
- New York State Health Research Science Board
- Cycle for Survival
- Center for Metastasis Research at MSKCC
- Lustgarten Distinguished Scholar Award
- Cancer Research UK [22310] Funding Source: researchfish
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Effective immunotherapy promotes the killing of cancer cells by cytotoxic T cells. This requires not only that cancer-specific Tcells be generated, but also that these Tcells physically contact cancer cells. The coexistence in some patients of cancer cells and T cells that recognize them indicates that tumors may exhibit the phenomenon of immune privilege, in which immunogenic tissue is protected from immune attack. Here, we review the evidence that stromal cells of the tumor microenvironment mediate this restriction by excluding T cells from the vicinity of cancer cells. Overcoming this T cell checkpoint may thus enable optimal immunotherapy.
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