Journal
SCIENCE
Volume 350, Issue 6261, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aab2006
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Funding
- Canadian Institute of Health Research
- Genome Quebec
- Reseau de Reproduction Quebecois
- Fonds de Recherche du Quebec - Nature et Technologies (FRQNT)
- Boehringer Ingelheim Fond
- Swiss National Science Foundation [31003A_125386]
- Novartis Research Foundation
- Swiss National Science Foundation (SNF) [31003A_125386] Funding Source: Swiss National Science Foundation (SNF)
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A father's lifetime experiences can be transmitted to his offspring to affect health and development. However, the mechanisms underlying paternal epigenetic transmission are unclear. Unlike in somatic cells, there are few nucleosomes in sperm, and their function in epigenetic inheritance is unknown. We generated transgenic mice in which overexpression of the histone H3 lysine 4 (H3K4) demethylase KDM1A (also known as LSD1) during spermatogenesis reduced H3K4 dimethylation in sperm. KDM1A overexpression in one generation severely impaired development and survivability of offspring. These defects persisted transgenerationally in the absence of KDM1A germline expression and were associated with altered RNA profiles in sperm and offspring. We show that epigenetic inheritance of aberrant development can be initiated by histone demethylase activity in developing sperm, without changes to DNA methylation at CpG-rich regions.
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