Journal
MOLECULAR BIOLOGY OF THE CELL
Volume 20, Issue 23, Pages 4976-4984Publisher
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E09-04-0295
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Funding
- INSERM
- Universite J. Fourier
- ARC [3449]
- CLARA
- University Toulouse III
- AIRC (Associazione Italiana Ricerca sul Cancro)
- French ministry of research
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A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation. Investigating the underlying mechanisms, we show that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-shock-dependent histone deacetylation. This work therefore identifies HSF1 as a master regulator of global chromatin acetylation and reveals a cross-talk between HSF1 and histone deacetylases in the general control of genome organization in response to heat shock.
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