Journal
SCIENCE
Volume 350, Issue 6263, Pages 981-985Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aac9593
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Funding
- Cancer Research Institute
- NIH [T32GM07739, R37AI034206]
- Cancer Center Support Grant from the NIH National Cancer Institute [P30CA008748]
- Ludwig Center at Memorial Sloan Kettering Cancer Center
- Hilton-Ludwig Cancer Prevention Initiative (Conrad N. Hilton Foundation)
- Hilton-Ludwig Cancer Prevention Initiative (Ludwig Cancer Research)
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Innate lymphoid cells (ILCs) contribute to barrier immunity, tissue homeostasis, and immune regulation at various anatomical sites throughout the body. How ILCs maintain their presence in lymphoid and peripheral tissues thus far has been unclear. We found that in the lymphoid and nonlymphoid organs of adult mice, ILCs are tissue-resident cells that were maintained and expanded locally under physiologic conditions, upon systemic perturbation of immune homeostasis and during acute helminth infection. However, at later time points after infection, cells from hematogenous sources helped to partially replenish the pool of resident ILCs. Thus, ILCs are maintained by self-renewal in broadly different microenvironments and physiological settings. Such an extreme sedentary lifestyle is consistent with the proposed roles of ILCs as sentinels and local keepers of tissue function.
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