Journal
SCIENCE
Volume 347, Issue 6226, Pages 1138-1142Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaa1934
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Funding
- European Research Council [261063, BRAINCELL, 294556, BBBARRIER]
- Swedish Research Council (STARGET)
- Human Frontier Science Program
- Karolinska Institutet (BRECT)
- Swedish Cancer Society [CAN2013/852]
- Swedish Research Council
- European Union (FP7/Marie Curie Integration Grant EPIOPC)
- Ake Wiberg Foundation
- Karolinska Institutet Research Foundations
- Svenska Lakaresallskapet
- Clas Groschinskys Minnesfond
- Hjarnfonden
- European Union [FP7/Marie Curie Actions] [322304]
- StratNeuro Foundation
- Jeanssons Foundation
- Ake Wibergs Foundation
- Magnus Bergvalls Foundation
- Knut and Alice Wallenberg Scholar Grant
- Swedish Cancer Society
- European Research Council (ERC) [294556] Funding Source: European Research Council (ERC)
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The mammalian cerebral cortex supports cognitive functions such as sensorimotor integration, memory, and social behaviors. Normal brain function relies on a diverse set of differentiated cell types, including neurons, glia, and vasculature. Here, we have used large-scale single-cell RNA sequencing (RNA-seq) to classify cells in the mouse somatosensory cortex and hippocampal CA1 region. We found 47 molecularly distinct subclasses, comprising all known major cell types in the cortex. We identified numerous marker genes, which allowed alignment with known cell types, morphology, and location. We found a layer I interneuron expressing Pax6 and a distinct postmitotic oligodendrocyte subclass marked by Itpr2. Across the diversity of cortical cell types, transcription factors formed a complex, layered regulatory code, suggesting a mechanism for the maintenance of adult cell type identity.
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