Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 29, Issue 7, Pages 1703-1706Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/mss014
Keywords
gene essentiality; yeast; mouse; phyletic age; linking genotype to phenotype
Funding
- SysteMtb [241587]
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Recently duplicated genes are believed to often overlap in function and expression. A priori, they are thus less likely to be essential. Although this was indeed observed in yeast, mouse singletons and duplicates were reported to be equally often essential. This contradiction can only partly be explained by experimental biases. We herein show that older genes (i.e., genes with earlier phyletic origin) are more likely to be essential, regardless of their duplication status. At a given phyletic gene age, duplicates are always less likely to be essential compared with singletons. The paradoxical high essentiality among mouse gene duplicates is then caused by different age profiles of singletons and duplicates, with the latter tending to be derived from older genes.
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