Journal
SCIENCE
Volume 349, Issue 6255, Pages 1489-1494Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaa8954
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Funding
- National Institute of Mental Health [5R01 MH100027, 5R01 MH094714]
- Simons Foundation [206744]
- Wellcome Trust
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Large-scale genomic investigations have just begun to illuminate the molecular genetic contributions to major psychiatric illnesses, ranging from small-effect-size common variants to larger-effect-size rare mutations. The findings provide causal anchors from which to understand their neurobiological basis. Although these studies represent enormous success, they highlight major challenges reflected in the heterogeneity and polygenicity of all of these conditions and the difficulty of connecting multiple levels of molecular, cellular, and circuit functions to complex human behavior. Nevertheless, these advances place us on the threshold of a new frontier in the pathophysiological understanding, diagnosis, and treatment of psychiatric disease.
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