Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 29, Issue 1, Pages 91-100Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msr149
Keywords
Ca2+ signaling; Ca2+ channel; evolutionary genomics; fungi; metazoan evolution
Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NICHD NIH HHS [U01 HD045857] Funding Source: Medline
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Animals and fungi diverged from a common unicellular ancestor of Opisthokonta, yet they exhibit significant differences in their components of Ca2+ signaling pathways. Many Ca2+ signaling molecules appear to be either animal-specific or fungal-specific, which is generally believed to result from lineage-specific adaptations to distinct physiological requirements. Here, by analyzing the genomic data from several close relatives of animals and fungi, we demonstrate that many components of animal and fungal Ca2+ signaling machineries are present in the apusozoan protist Thecamonas trahens, which belongs to the putative unicellular sister group to Opisthokonta. We also identify the conserved portion of Ca2+ signaling molecules in early evolution of animals and fungi following their divergence. Furthermore, our results reveal the lineage-specific expansion of Ca2+ channels and transporters in the unicellular ancestors of animals and in basal fungi. These findings provide novel insights into the evolution and regulation of Ca2+ signaling critical for animal and fungal biology.
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