Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 29, Issue 3, Pages 883-886Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msr263
Keywords
low-complexity sequence; gene age; protein domain evolution
Funding
- Ministerio de Educacion
- Fundacion Javier Lamas
- Ministerio de Innovacion y Tecnologia [BIO2009-08160]
- Institucio Catalana de Recerca i Estudis Avancats
- ICREA Funding Source: Custom
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Low-complexity sequences are extremely abundant in eukaryotic proteins for reasons that remain unclear. One hypothesis is that they contribute to the formation of novel coding sequences, facilitating the generation of novel protein functions. Here, we test this hypothesis by examining the content of low-complexity sequences in proteins of different age. We show that recently emerged proteins contain more low-complexity sequences than older proteins and that these sequences often form functional domains. These data are consistent with the idea that low-complexity sequences may play a key role in the emergence of novel genes.
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