Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 28, Issue 8, Pages 2359-2369Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msr058
Keywords
nonsynonymous substitution; synonymous substitution; gene duplication; gene expression
Funding
- National Science Foundation [DEB-0723860]
- Direct For Biological Sciences
- Division Of Environmental Biology [0723860] Funding Source: National Science Foundation
Ask authors/readers for more resources
Surprisingly, few studies have described evolutionary rate variation among plant nuclear genes, with little investigation of the causes of rate variation. Here, we describe evolutionary rates for 11,492 ortholog pairs between Arabidopsis thaliana and A. lyrata and investigate possible contributors to rate variation among these genes. Rates of evolution at synonymous sites vary along chromosomes, suggesting that mutation rates vary on genomic scales, perhaps as a function of recombination rate. Rates of evolution at nonsynonymous sites correlate most strongly with expression patterns, but they also vary as to whether a gene is duplicated and retained after a whole-genome duplication (WGD) event. WGD genes evolve more slowly, on average, than nonduplicated genes and non-WGD duplicates. We hypothesize that levels and patterns of expression are not only the major determinants that explain nonsynonymous rate variation among genes but also a critical determinant of gene retention after duplication.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available