Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 27, Issue 11, Pages 2437-2440Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msq139
Keywords
Y chromosome; SRY; gene conversion; Oryctolagus cuniculus
Funding
- Fundacao para a Ciencia e a Tecnologia [PTDC/BIA-BDE/72304/2006, SFRH/BD/4621/2001]
- National Science Foundation and National Institute of Health
- Fundação para a Ciência e a Tecnologia [SFRH/BD/4621/2001, PTDC/BIA-BDE/72304/2006] Funding Source: FCT
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The human Y chromosome consists of ampliconic genes, which are located in palindromes and undergo frequent gene conversion, and single-copy genes including the primary sex-determining locus, SRY. Here, we demonstrate that SRY is duplicated in a large palindrome in the European rabbit (Oryctolagus cuniculus). Furthermore, we show through comparative sequencing that orthologous palindrome arms have diverged 0.40% between rabbit subspecies over at least 2 My, but paralogous palindrome arms have remained nearly identical. This provides clear evidence of gene conversion on the rabbit Y chromosome. Together with previous observations in humans, these results suggest that gene conversion is a general feature of the evolution of the mammalian Y chromosome.
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