4.8 Article

Polymorphisms in the CPB2 Gene Are Maintained by Balancing Selection and Result in Haplotype-Preferential Splicing of Exon 7

Journal

MOLECULAR BIOLOGY AND EVOLUTION
Volume 27, Issue 8, Pages 1945-1954

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/molbev/msq082

Keywords

balancing selection; thrombin-activatable fibrinolysis inhibitor; alternative splicing; CPB2

Funding

  1. Italian Ministry of Health [RF-IEM-2007-633627]

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These data highlight the contribution of population genetics approaches to the analysis of functional genetic variation and may orient further biochemical and genetics studies on the pathophysiolgic role of CPB2 gene products.

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