Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 26, Issue 6, Pages 1195-1198Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msp053
Keywords
microRNA expression; sequence divergence; spatial clustering; selective pressure
Funding
- National Institutes of Health [GM30998, GM081724]
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To study the evolution of human microRNAs (miRNAs), we examined nucleotide variation in humans, sequence divergence between species, and genomic clustering patterns for miRNAs with different expression levels. We found that expression level is a major indicator of the rate of evolution and that similar to 30% of currently annotated human miRNA genes are almost free of selective pressure.
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