Journal
SCIENCE
Volume 350, Issue 6265, Pages 1251-1255Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aad2456
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Funding
- Howard Hughes Medical Institute
- NIH [R01 DC009324, DP2 HD088158]
- Alfred P. Sloan Fellowship
- Damon Runyon Cancer Research Foundation
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The sense of smell allows chemicals to be perceived as diverse scents. We used single-neuron RNA sequencing to explore the developmental mechanisms that shape this ability as nasal olfactory neurons mature in mice. Most mature neurons expressed only one of the similar to 1000 odorant receptor genes (Olfrs) available, and at a high level. However, many immature neurons expressed low levels of multiple Olfrs. Coexpressed Olfrs localized to overlapping zones of the nasal epithelium, suggesting regional biases, but not to single genomic loci. A single immature neuron could express Olfrs from up to seven different chromosomes. The mature state in which expression of Olfr genes is restricted to one per neuron emerges over a developmental progression that appears to be independent of neuronal activity involving sensory transduction molecules.
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