Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 25, Issue 8, Pages 1728-1736Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msn124
Keywords
founder events; multiple mating; X-linked variation; autosomal variation; Drosophila melanogaster
Funding
- NHGRI NIH HHS [F32 HG004182] Funding Source: Medline
- NHLBI NIH HHS [UO1HL084706, U01 HL084706] Funding Source: Medline
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In species with heterogametic males, the relative levels of X chromosome versus autosome diversity hold key information about the evolutionary forces at work in a population. It has been shown that population size changes alter the ratio of X linked to autosomal (X/A) variation, with population size reductions and recent bottlenecks leading to decreased X/A diversity ratios. Here we use theory and simulation to investigate a separate demographic effect-that of founder events involving multiply mated females-and find that it leads to much stronger reductions in X/A diversity ratios than are produced by simple population size changes. Investigating the potential of this process to account for sharply reduced X-linked diversity in European Drosophila melanogaster, we find that this model yields predictions that are compatible with the empirical data.
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