Journal
MOLECULAR BIOLOGY
Volume 48, Issue 1, Pages 16-28Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0026893314010063
Keywords
DEAD-box RNA helicases; DDX3; Vasa; Spindle-E; oogenesis; spermatogenesis; RNA silencing
Categories
Funding
- program Molecular and Cell Biology of the Presidium of the Russian Academy of Sciences and the Russian Foundation for Basic Research [12-04-31155, 12-04-33093, 13-04-00699]
Ask authors/readers for more resources
The review summarizes a current knowledge about a role of RNA helicases in the development and maintenance of gamenogenesis in eukaryotes. We focused on three RNA helicase family members-Vasa/DDX4, Belle/DDX3, and Spindle-E/TDRD9-that contain characteristic amino acid sequence motifs (DEAD box) and perform substantial conserved functions in the germinal tissues of various species from Drosophila to human. These enzymes are involved in a broad range of activities associated with the regulation of transcription, splicing, nuclear export and, especially, with translation initiation. Expression of genes required for gametogenesis is regulated mainly at the transcriptional level. RNA helicases are involved in the formation of cytoplasmic ribonucleoprotein (RNP) granules and RNA silencing. A highly conserved central domain is characteristic of DEAD-box RNA helicases and determines their basic biological activity in ATP-dependent unwinding of short RNA duplexes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available