Journal
MOLECULAR BIOLOGY
Volume 47, Issue 5, Pages 622-633Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0026893313050130
Keywords
prenylation; mechanism; PrePS; prenylation inhibitors; Francisella; SifA; AnkB proteins
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Funding
- Mary Louise Andrews Award for Cancer Research program
- Ministry of Education and Science of the Russian Federation [14.512.11.0090, 8273, 2012-1.1-12-000-2008-067]
- Human Proteome Project Program of the Russian Academy of Medical Sciences
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For their protection from host cell immune defense, intracellular pathogens of eukaryotic cells developed a variety of mechanisms, including secretion systems III and IV which can inject bacterial effectors directly into eukaryotic cells. These effectors may function inside the host cell and may be posttranslationally modified by host cell machinery. Recently, prenylation was added to the list of possible posttranslational modifications of bacterial proteins. In this work we describe the current state of the knowledge about the prenylation of eukaryotic and prokaryotic proteins and prenylation inhibitors. The bioinformatics analyses suggest the possibility of prenylation for a number of Francisella genus proteins.
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