Journal
MOLECULAR BIOLOGY
Volume 45, Issue 1, Pages 150-155Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0026893311010079
Keywords
apoptosis; death receptor; CD95 (Fas/APO-1)
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Funding
- SBCancer
- Helmholtz-Russia Joint Research Groups
- Russian Foundation for Basic Research [09-04-91320]
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Apoptosis (programmed cell death) is common to all multicellular organisms. Apoptosis plays a central role in cell differentiation, removal of damaged cells, and the homeostasis of the immune system. There are two apoptosis signal pathways: the extrinsic (transmitted through death receptors (DR)) or the intrinsic (mitochondrial) death pathways. A death receptor, CD95 (Fas/APO-1), was discovered 20 years ago. This review is focused on the mechanisms of death receptor-induced apoptosis via CD95 (Fas/APO-1)-mediated apoptosis and the role of the antiapoptotic protein c-FLIP in the extrinsic apoptosis regulation. The regulation of this pathway is crucial for the immune system. Defects in the regulation of CD95-mediated result in serious diseases such as cancer, autoimmunity, and AIDS. Therefore, gaining insights into apoptosis will have wide implications for developing approaches to treatment strategies of these diseases.
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