Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 38, Issue -, Pages 54-85Publisher
ELSEVIER
DOI: 10.1016/j.mam.2013.06.001
Keywords
Infertility; Maternal age; Oocyte; Ovary; Assited reproductive technology
Funding
- Major State Basic Research Program [2011CB944500, 2012CB944404]
- National Natural Science Foundation of China [30930065]
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It is well known that maternal ageing not only causes increased spontaneous abortion and reduced fertility, but it is also a high genetic disease risk Although assisted reproductive technologies (ARTs) have been widely used to treat infertility, the overall success is still low. The main reasons for age-related changes include reduced follicle number, compromised oocyte quality especially aneuploidy, altered reproductive endocrinology, and increased reproductive tract defect. Various approaches for improving or treating infertility in aged women including controlled ovarian hyperstimulation with intrauterine insemination (IUI), IVF/ICSI-ET, ovarian reserve testing, preimplantation genetic diagnosis and screening (PGD/PGS), oocyte selection and donation, oocyte and ovary tissue cryopreservation before ageing, miscarriage prevention, and caloric restriction are summarized in this review. Future potential reproductive techniques for infertile older women including oocyte and zygote micromanipulations, derivation of oocytes from germ stem cells, ES cells, and iPS cells, as well as through bone marrow transplantation are discussed. (C) 2013 Elsevier Ltd. All rights reserved.
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