Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 34, Issue 2-3, Pages 516-528Publisher
ELSEVIER
DOI: 10.1016/j.mam.2012.07.010
Keywords
SLC27; FATP; Fatty acid transport proteins; Fatty acid uptake; Fatty acid activation
Funding
- NIH [R01DK089202-01A1, R01 DK066336-08]
- Swiss National Science Foundation through the National Center of Competence in Research (NCCR) TransCure, University of Bern, Switzerland
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The uptake and metabolism of long chain fatty acids (LCFA) are critical to many physiological and cellular processes. Aberrant accumulation or depletion of LCFA underlie the pathology of numerous metabolic diseases. Protein-mediated transport of LCFA has been proposed as the major mode of LCFA uptake and activation. Several proteins have been identified to be involved in LCFA uptake. This review focuses on the SLC27 family of fatty acid transport proteins, also known as FATPs, with an emphasis on the gain- and loss-of-function animal models that elucidate the functions of FATPs in vivo and how these transport proteins play a role in physiological and pathological situations. (C) 2012 Elsevier Ltd. All rights reserved.
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