Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 34, Issue 2-3, Pages 236-251Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mam.2012.05.001
Keywords
SLC9; Na/H exchanger gene family; Antiporter; 1:1 stoichiometry; Na absorption; Intracellular pH
Funding
- National Institutes of Health, NIDDK (The Hopkins Basic Research Digestive Diseases Development Core Center) [RO1-DK26523, RO1-DK061765, PO1-DK072084, R24-DK64388]
- Swiss National Science Foundation [3100A0-117732]
- Medical Research Position Award of the Foundation Prof. Dr. Max Cloetta
- Swiss National Science Foundation through the National Center of Competence in Research (NCCR) TransCure, University of Bern, Switzerland
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This brief review of the human Na/H exchanger gene family introduces a new classification with three subgroups to the SLC9 gene family. Progress in the structure and function of this gene family is reviewed with structure based on homology to the bacterial Na/H exchanger NhaA. Human diseases which result from genetic abnormalities of the SLC9 family are discussed although the exact role of these transporters in causing any disease is not established, other than poorly functioning NHE3 in congenital Na diarrhea (C) 2012 Elsevier Ltd. All rights reserved.
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