Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 34, Issue 4, Pages 875-882Publisher
ELSEVIER
DOI: 10.1016/j.mam.2012.06.011
Keywords
Chromatin; Epigenetic; Histone deacetylase; Histone modification; Neurodegenerative disease; Non-coding RNA
Funding
- National Institutes of Health [NS071571, HD071593, MH66290]
- F.M. Kirby
- Alpem Family
- Mildred and Bernard H. Kayden
- Roslyn and Leslie Goldstein Foundations
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Studies elucidating how and why neurodegeneration unfolds suggest that a complex interplay between genetic and environmental factors is responsible for disease pathogenesis. Recent breakthroughs in the field of epigenetics promise to advance our understanding of these mechanisms and to promote the development of useful and effective pre-clinical risk stratification strategies, molecular diagnostic and prognostic methods, and disease-modifying treatments. (C) 2012 Elsevier Ltd. All rights reserved.
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