Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 34, Issue 4, Pages 765-781Publisher
ELSEVIER
DOI: 10.1016/j.mam.2012.06.006
Keywords
Epigenetics; Aging; DNA methylation; Histone modifications; Adult stein cells
Funding
- FIS [F107/00380]
- IUOPA
- Miguel Servet program
- Spanish Ministry of Health [PI061267, PS09/02454]
- Spanish National Research Council [CSIC 2008201172]
- Community of Asturias (FICYT) [IB09-106]
- Obra Social Cajastur, Spain
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Growth and development of higher organisms are regulated by the orchestrated change of epigenetic marks over time. In addition, there is also an epigenetic variation without any apparent role in development that is thought to be the result of the stochastic accumulation of epigenetic errors. The process depends on genetic and environmental factors and, when it takes place in adult stem cells, it could play an important role in aging, although the underlying molecular mechanisms are still largely unknown. (C) 2012 Elsevier Ltd. All rights reserved.
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