Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 33, Issue 5-6, Pages 691-703Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mam.2012.01.002
Keywords
Aquaporin (AQP); Drug discovery; Pharmacotherapy; Imaging
Funding
- Ministry of Culture, Science, Sports and Technology (MEXT)
- University of Niigata Center for Transdisciplinary Studies
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Identification of the aquaporin (AQP) protein family more than twenty years ago has ushered in an era where water and neutral solute trafficking is considered a prime target for pharmacological intervention. Using AQP modulation as a basis for the treatment of human disorders has been suggested by phenotype analysis involving specific AQP-null animals, as well as by pathohistological studies. Based on those reports, a wide variety of disorders, such as cerebral edema, cancer and malaria, are considered indications for AQP modulators. Recent studies have also identified several small molecule AQP modulators that can be used to test those hypotheses in disease models. We believe these studies and compounds form the basis from which future treatments and diagnostic protocols of aquaporin-based disorders will be developed. (C) 2012 Elsevier Ltd. All rights reserved.
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