Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 32, Issue 2, Pages 88-111Publisher
ELSEVIER
DOI: 10.1016/j.mam.2011.04.004
Keywords
VEGFA; VEGF receptors; Neuropilin; Anti-angiogenesis; Sunitinib; Sorafenib; Bevacizumab
Funding
- Uppsala University
- Swedish Cancer Foundation
- Swedish Science Council
- Wallenberg Foundation
- Spanish Ministry of Science and Education (MEC)
- Spanish Association of Liver Diseases (AEEH)
- Gustaf Adolf Johansson's Foundation, at Uppsala University
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Vascular endothelial growth factors (VEGFs) are critical regulators of vascular and lymphatic function during development, in health and in disease. There are five mammalian VEGF ligands and three VEGF receptor tyrosine kinases. In addition, several VEGF co-receptors that lack intrinsic catalytic activity, but that indirectly modulate the responsiveness to VEGF contribute to the final biological effect. This review describes the molecular features of VEGFs. VEGFRs and co-receptors with focus on their role in the treatment of cancer. (C) 2011 Elsevier Ltd. All rights reserved.
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