Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 32, Issue 2, Pages 146-158Publisher
ELSEVIER
DOI: 10.1016/j.mam.2011.04.002
Keywords
Lymphangiogenesis; Extracellular matrix; Interstitial tissue; Cell-cell junctions; Integrins; Metalloproteases
Funding
- Fondation Contre le Cancer [201279]
- Direction Generale Operationnelle de l'Economie, de l'Emploi et de la Recherche from the S.P.W. (Service Public de Wallonie, Belgium) [616476]
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The main physiological function of the lymphatic vasculature is to maintain tissue fluid homeostasis. Lymphangiogenesis or de novo lymphatic formation is closely associated with tissue inflammation in adults (i.e. wound healing, allograft rejection, tumor metastasis). Until recently, research on lymphangiogenesis focused mainly on growth factor/growth factor-receptor pathways governing this process. One of the lymphatic vessel features is the incomplete or absence of basement membrane. This close association of endothelial cells with the underlying interstitial matrix suggests that cell-matrix interactions play an important role in lymphangiogenesis and lymphatic functions. However, the exploration of interaction between extracellular matrix (ECM) components and lymphatic endothelial cells is in its infancy. Herein, we describe ECM-cell and cell-cell interactions on lymphatic system function and their modification occurring in pathologies including cancer metastasis. (C) 2011 Elsevier Ltd. All rights reserved.
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