Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 31, Issue 5, Pages 398-406Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mam.2010.05.002
Keywords
HIV; Vpr; Vpx; Cell cycle; Ubiquitin ligase; ATR
Funding
- NIH [AI49057, AI52809, AI56923]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI087508, R01AI065361, R03AI052809, R56AI049057, R21AI056923, R01AI049057] Funding Source: NIH RePORTER
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The human and simian immunodeficiency viruses contain small open reading frames known as vpr and vpx. These genes encode proteins that are highly related both at the amino acid level and functionally, although key differences do exist. This review describes the main functions ascribed to Vpr and Vpx in the context of both viral replication and modulation of host cell biology. (C) 2010 Elsevier Ltd. All rights reserved.
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