Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 30, Issue 6, Pages 439-455Publisher
ELSEVIER
DOI: 10.1016/j.mam.2009.07.003
Keywords
Anthrax; Lethal toxin; Edema toxin; Pathogenesis; Animal models
Funding
- Intramural NIH HHS [Z01 AI000929-05] Funding Source: Medline
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Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and can replicate the lethality and symptoms associated with the disease. This review provides an overview of our current understanding of anthrax toxin effects in animal models and the cytotoxicity (necrosis and apoptosis) induced by LT in different cells. A brief reexamination of early historic findings on toxin in vivo effects in the context of our current knowledge is also presented. Published by Elsevier Ltd.
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