Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 30, Issue 6, Pages 431-438Publisher
ELSEVIER
DOI: 10.1016/j.mam.2009.07.006
Keywords
Anthrax; Lethal factor; Metalloprotease; MAPK kinase; Botulinum neurotoxins
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The anthrax lethal factor is a multi-domain protein toxin released by Bacillus anthracis which enters cells in a process mediated by the protective antigen and specific cell receptors. In the cytosol, the lethal factor cleaves the N-terminal tail of many MAPK kinases, thus deranging a major cell signaling pathway. The structural features at the basis of these activities of LF are reviewed here with particular attention to the proteolytic activity and to the identification of specific inhibitors. A significant similarity between the metalloprotease domain of the lethal factor and of that of the clostridial neurotoxins has been noted and is discussed. (C) 2009 Elsevier Ltd. All rights reserved.
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