Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 30, Issue 1-2, Pages 1-12Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mam.2008.08.006
Keywords
Glutathione; Glutamate cysteine ligase; Hydroperoxide; Xenobiotic; Methods
Funding
- NIEHS NIH HHS [R01 ES005511-20, R01 ES005511] Funding Source: Medline
Ask authors/readers for more resources
This review is the introduction to a special issue concerning, glutathione (GSH), the most abundant low molecular weight thiol compound synthesized in cells. GSH plays critical roles in protecting cells from oxidative damage and the toxicity of xenobiotic electrophiles. and maintaining redox homeostasis. Here, the functions and GSH and the sources of oxidants and electrophiles, the elimination of oxidants by reduction and electrophiles by conjugation with GSH are briefly described. Methods of assessing GSH status in the cells are also described. GSH synthesis and its regulation are addressed along with therapeutic approaches for manipulating GSH content that have been proposed. The purpose here is to provide a brief overview of some of the important aspects of glutathione metabolism as part of this special issue that will provide a more comprehensive review of the state of knowledge regarding this essential molecule. (C) 2008 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available