Journal
MOLECULAR AND CELLULAR PROBES
Volume 26, Issue 1, Pages 54-59Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.mcp.2011.10.001
Keywords
Ancylostoma-secreted proteins; Classification; Bioinformatics; Vaccine candidates; Phylogeny; Structural biology
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Funding
- Australian Research Council (ARC)
- National Health and Medical Research Council (NHMRC)
- Melbourne Water Corporation
- Pfizer Inc.
- Australian Government
- University of Melbourne
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A diverse array of proteins belonging to the SCP/TAPS 'family' has been described for various eukaryotic organisms, including parasites. Although SCP/TAPS proteins have been hypothesized to play key roles in various fundamental biological processes, such as host-pathogen interactions and defence mechanisms, there is still a limited understanding of the precise roles of these proteins. Here, we review current knowledge of key SCP/TAPS proteins of helminths and their proposed roles in parasite-host interactions. Molecular investigations of these molecules in parasites and the integration of structural and functional data could lead to new and innovative approaches for the treatment and control of parasitic diseases, with important biotechnological outcomes. (C) 2011 Published by Elsevier Ltd.
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