Journal
MOLECULAR AND CELLULAR NEUROSCIENCE
Volume 55, Issue -, Pages 13-16Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2012.07.005
Keywords
Mitochondria; Oxidative stress; Reactive oxygen species
Categories
Funding
- National Institutes of Health/National Institute on Aging [AG 14930]
Ask authors/readers for more resources
The activity of mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) is severely reduced in human pathologies where oxidative stress is traditionally thought to play an important role, such as familial and sporadic forms of Alzheimer's disease and other age-related neurodegenerative diseases. This minireview is focused on substantial data that were accumulated over the last 2 decades to support the concept that KGDHC can be a primary mitochondrial target of oxidative stress and at the same time a key contributor to it by producing reactive oxygen species. This article is part of a Special Issue entitled Mitochondrial function and dysfunction in neurodegeneration'. (C) 2012 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available