Journal
SCIENCE
Volume 350, Issue 6267, Pages 1552-1555Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aac7504
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Funding
- Howard Hughes Medical Institute-Life Sciences Research Foundation (HHMI-LSRF) postdoctoral fellowship
- Mario Cappecchi-endowed assistant professorship
- NIH Developmental Biology Training Grant [5T32 HD0741]
- NSF [DGE-071824]
- NIH [R01 GM115914, HG006283, R01 GM074108]
- Mathers Foundation
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Speciation, the process by which new biological species arise, involves the evolution of reproductive barriers, such as hybrid sterility or inviability between populations. However, identifying hybrid incompatibility genes remains a key obstacle in understanding the molecular basis of reproductive isolation. We devised a genomic screen, which identified a cell cycle-regulation gene as the cause of male inviability in hybrids resulting from a cross between Drosophila melanogaster and D. simulans. Ablation of the D. simulans allele of this gene is sufficient to rescue the adult viability of hybrid males. This dominantly acting cell cycle regulator causes mitotic arrest and, thereby, inviability of male hybrid larvae. Our genomic method provides a facile means to accelerate the identification of hybrid incompatibility genes in other model and nonmodel systems.
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