Journal
MOLECULAR AND CELLULAR NEUROSCIENCE
Volume 44, Issue 4, Pages 394-403Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2010.05.005
Keywords
Lmx1b; Drg11; Transcription factor; Pattern formation; Barrels; Whiskers
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Funding
- National Institutes of Health (NIH) [R01-NS046036, P01-NS049048]
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Little is known of transcriptional mechanisms underlying the development of the trigeminal (V) principal sensory nucleus (PrV), the brainstem nucleus responsible for the development of the whisker-to-barrel cortex pathway. Lmx1b, a LIM homeodomain transcription factor, is expressed in embryonic PrV. In Lmx1b knockout ((-/-)) mice, V primary afferent projections to PrV are normal, albeit reduced in number, whereas the PrV-thalamic lemniscal pathway is sparse and develops late. Excess cell death occurs in the embryonic Lmx1b(-/-) PrV, but not in Lmx1b/Bax double null mutants. Expression of Drg11, a downstream transcription factor essential for PrV development and pattern formation, is abolished in PrV, but not in the V ganglion. Consequently, whisker patterns fail to develop in PrV by birth. Rescued PrV cells in Lmx1b/Bax double(-/-)s failed to rescue whisker-related Pry pattern formation. Thus. Lmx1b and Drg11 may act in the same genetic signaling pathway that is essential for PrV pattern formation. (C) 2010 Elsevier Inc. All rights reserved.
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