Journal
MOLECULAR AND CELLULAR NEUROSCIENCE
Volume 41, Issue 3, Pages 304-312Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2009.04.001
Keywords
LGN; Mapping; Segregation; Retinal activity; Mouse; Presynaptic
Categories
Funding
- Horncrest Foundation
- McDonnell Center for Higher Brain Function
- Knights Templar Foundation
- Keck Foundation and NIH [DA020812]
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Proper functioning of the mammalian visual system requires that connections between the eyes and their central targets develop precisely. At birth. axons from the two eyes project to broad, overlapping regions of the dorsal-lateral geniculate nucleus (dLGN). In the adult, retinal axons segregate into distinct monocular regions at stereotyped locations within the dLGN. This process is driven by both molecular cues and activity-dependent synaptic competition. Here we demonstrate that Phr1, an evolutionarily conserved regulator of synapse formation and axon guidance, defines a novel molecular pathway required for proper localization of retinogeniculate projections. Following conditional excision of Phr1 in the retina, eye-specific domains within the dLGN are severely disturbed, despite normal spontaneous retinal wave activity and monocular segregation. Although layer placement is dramatically altered, Phr1 mutant retinal axons respond to ephrin-A in vitro. These findings indicate that Phr1 is a key presynaptic regulator of retinogeniculate layer placement independent of activity, segregation, or ephrin-A signaling. (C) 2009 Elsevier Inc. All rights reserved.
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